Use of histidine derivatives in pharmaceuticals as novel cyclic compounds
DOI:
https://doi.org/10.64601/9hexft12Keywords:
Histidine derivatives, C.H.N. analysis, FT-IRAbstract
The study involved the preparation of several new histidine derivatives through multiple pathways. In the first pathway, histidine was treated with absolute ethanol and parachlorobenzylaldehyde in the presence of concentrated sulfuric acid to obtain derivative (1). In the second pathway, histidine was treated with parahydroxyacetone phenone and absolute ethanol in the presence of concentrated sulfuric acid to obtain derivative (2). Both chemical reactions were monitored using thin-layer chromatography (TLC). The physical properties of the prepared compounds were also investigated using elemental analysis (C.H.N. analysis) and spectroscopic methods (FT-IR, ¹H NMR, ¹³HSQC, HMBC).
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