Investigation of the role of selenium on some fertility and sex hormones in infertile men
Keywords:
Male infertility, Selenium, Treatment, Sperm Count, Sperm Morphology, FSH, LH, TestosteronAbstract
Infertility continues to be one of the biggest problems of human history, and the desire of humans to exist in future generations is due to emotional reasons. In the last 50 years, about 10-15% of couples have infertility.
The male factor is effective in 30-40% of all infertile couples, and the female factor is effective in 40-50%. In 15% of the couples, no cause of infertility can be determined as a result of all diagnostic tests, and it has been defined as unexplained infertility.
Based on these considerations, it was aimed to investigate the element levels important in male fertilization and to determine the relationship between spermiogram parameters and trace element (se) levels in infertile men, and serum and semen anti-Müllerian, Follicle stimulating hormone (FSH), luteinizing hormone in fertile and infertile men. (LH) testosterone was evaluated as spermatogenesis markers.
Our study was carried out in Al-Hussein Education and Research Hospital in Thi-Qar Province. 100 infertile male patients were included in our study by forming an experimental group, taking into account various criteria. For hormone analysis, all blood was taken in patients on an empty stomach in the morning. Folliculstimulant hormone (FSH), LH, and total testosterone determinations were made. Being over 18 years old. - - Not using any medication that will affect the study results, not having any other disease. - Not receiving cancer treatment, chemotherapy and radiotherapy treatment. - 96 hours of sexual abstinence prior to sample collection. Semen analysis was performed according to the analysis criteria specified by WHO.
FSH, LH, and testosterone levels were measured in serum and semen of all cases. Serum and seminal plasma levels of anti-Müllerian hormone were found to be significantly lower in patients with azoospermia compared to controls. Decreased blood plasma anti-Müllerian hormone levels were positively correlated with seminal plasma testosterone levels.
Selenium level is significantly lower in oligozoospermic individuals (66.51 ± 10.26 µg / L) compared to normozoospermic (296.49 36.088 µg / L) individuals. In conclusion, the concentrations of trace elements known to have roles in fertilization in seminal plasma indicate that they have toxic effects and effects on various biological pathways that cause infertility. The fact that the excess of the elements can be an indicator of infertilization is another finding that can be said in line with the relationship of these elements with the spermiogram results. It is thought that the obtained data will contribute to further studies.
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