Gastro-retentive drug delivery systems: a brief review
Keywords:
GRDDS, gastric retention time, floating systems, gastro-retention, high density systems, low density systemsAbstract
In pharmaceutical companies, floating tablets are used for sustained drug delivery. It also enables the development of tablet formulation with different drug release profiles. These tablets remain buoyant in the stomach, thereby increasing the gastric residence time and hence the effect of the drug. These tablets have bulk density less than that of gastric fluid. Such drugs are released very slowly over the food material and taken up by esophagus. It can increase the GRT and controls the fluctuations in drug plasma concentration.
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