Analysis on rose periwinkle confront against harmful agent
Keywords:
Rose Periwinkle, anticancer alkaloids, traditional medicine, vincristine, vinblastineAbstract
Rose Periwinkle is a well-known Ayurvedic herb. Its antitumor, anti-diabetic, anti-microbial, anti-oxidant, and antimutagenic properties are well-known. It is gaining popularity because of discovery of a variety of phytochemicals with varied biological activities. The Catharanthus alkaloids have a necessary role in clinical medicine, with vincristine (VCR) and vinblastine (VLB) being key components of typical chemotherapy regimens. In the instance of Rose Periwinkle, the shift from traditional to modern treatment was quick. Leads obtained from Rose Periwinkle have demonstrated that natural goods are actually reliable sources of medicine and can repair a variety of human health issues. The traditional use and alkaloids profiles of Rose Periwinkle are discussed in researches. These researches should be used to further understand the health-promoting qualities of this versatile plant, and it could also lead to the development of a novel lead molecule with significant medicinal potential. vinblastine, it has a lot of therapeutic potential that has to be investigated further.
References
Bennouna J, Delord JP, Campone M, Nguyen L. Vinflunine. A new microtubule inhibitor agent. Clin Cancer Res, 2008; 14:1625-32.
Brun G, Dijoux MG, David B, Mariotte AM. A new flavonol glycoside from Rose Periwinkle. Phytochemistry, 1999; 50:167-169.
Farnsworth NR. Plants and Modern Medicine: Where science and folklore meet. Traditional Medicine, World Health Forum, 1985; 6:76-80.
Foye William O. Cancer Chemotherapeutic Agents. American Chemical Society, Washington, DC, 1995, 349- 53.
Gajalakshmi S. Pharmacological activities of Rose Periwinkle: A Perspective Review. Journal of the American Chemical Society, 2013; 42:431-439B.
Jacobs DI, Snoeijer W, Hallard D, Verpoorte R. The Catharanthus alkaloids: pharmacognosy and biotechnology. Current medicinal chemistry, 2004; 11(5):607-628.
Uniyal GC, Bala S, Mathur AK, Kulkarni RN. Symmetry C18 column: a better choice for the analysis of indole alkaloids of Rose Periwinkle. Phytochemical analysis, 2001; 12(3):206-210.
Jordan MA. Mechanism of action of antitumor drugs that interact with microtubules and tubulin. Current Medicinal Chemistry-Anti-Cancer Agents, 2002; 2(1):1-17.
Singh K, Swanson B, Singh J. Development of supply chains for medicinal plants: a case study involving the production of vinca rosa by small farmers in the Patna District of Bihar India in Workshop on Building New Partnerships in the Global Food Chain, Chicago, 2005.
Tamizhazhagan V, Pugazhendy K, Sakthidasan V, Jayanthi C. Preliminary screening of phytochemical evaluation selected plant of Pisonia alba. IJ Biol. Research, 2017; 2(4):63-66.
Thompson WAR. Herbs that heal. J Roy Coll Gen Pract, 1976; 26:365-370.
Yogesh Patel, et al. Evaluation of hypolipidemic activity of leaf juice of Rose Periwinkle (Linn.). Acta Poloniae Pharmaceutica - Drug Research, 2011; 68(6):927-935.
Zhou ML, Shao JR, Tang YX. Production and metabolic engineering of terpenoid indole alkaloids in cell cultures of the medicinal plant Rose Periwinkle (L.) G. Don (Madagascar periwinkle). Biotechnology and applied biochemistry, 2009; 52(4):313-323.
